IndraLab

Statements

OTUD3 increases the amount of YY1. 3 / 3
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"Over-expression of OTUD3 significantly increased YY1 protein expression and suppressed its ubiquitination, whereas OTUD3 knockdown or knockout increased YY1 degradation."
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"Ectopic expression of wild-type OTUD3, instead of the catalytically inactive mutant OTUD3-C76A, increased YY1 protein levels (Fig. 2E, F)."
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"Similarly, in OTUD3 knockout SW480 cells (generated using CRISPR/Cas9), ectopic expression of wild-type OTUD3, instead of mutant OTUD3, restored YY1 protein levels (Fig. 2G)."
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