IndraLab

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COPS5 activates SMAD7. 2 / 2

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"Here we report that Jab1 and CSN5, which is a component of the COP9 signalosome complex, associates constitutively with Smad7 and that overexpression of Jab1 and CSN5 causes the translocation of Smad7 from the nucleus to the cytoplasm, promoting its degradation."

14993265

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"By degrading Smad4 or Smad7, Jab1 can repress or increase TGF-beta and BMP signaling, respectively, in vitro."

24604556

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IndraLab

Statements

COPS5 activates SMAD7. 2 / 2

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