IndraLab

Statements

USP3 activates Neoplasm Metastasis. 18 / 18
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"USP3 can accelerate gastric cancer metastasis by enhancing the COL9A3/COL6A5 stability via deubiquitination [48]."
37980532
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"Silencing of USP3 suppressed GC cell proliferation and spreading in vitro as well as xenograft proliferation and metastasis in vivo; however, opposite results were obtained when USP3 was overexpressed."
30168892
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"USP3 acts as a deubiquitinase of Aurora A to promote metastasis of esophageal squamous cell carcinoma [53]."
37980532
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"Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma."
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"The upregulation of USP3 in GC has been found to significantly enhance cell proliferation in vitro and promote metastasis in vivo [36, 37]."
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"And study revealed that USP3 promotes the proliferation and metastasis of esophageal squamous cell carcinoma by stabilizing Aurora A [41]."
38531846
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"Therefore, the development of an effective inhibitor with this target is expected to become an important method for the treatment of OS.In conclusion, USP3 promotes the proliferation and metastasis of OS."
38531846
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"Existing studies have shown that USP3 promotes cancer progression and metastasis through its deubiquitination function [17]."
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"Here, we report that ubiquitin specific peptidase 3 (USP3) promotes proliferation and metastasis of esophageal squamous cell carcinoma (ESCC) cells by mediating deubiquitination of Aurora A. Analysis of human clinical samples indicated that USP3 and Aurora A are highly expressed in ESCC."
34758762
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"These data suggest that USP3 promotes GC progression and metastasis by deubiquitinating COL9A3 and COL6A5 ."
34930901
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"Through the deubiquitination of the K143 residue of Aurora A, a serine/threonine kinase associated with centrosomes and mitosis, USP3 promotes invasion and metastasis in ESCC cells."
38651282
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"USP3 knockdown induced metastasis was abolished by USP3 3 ' UTR overexpression in CRC cells."
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"However, the mechanism by which USP3 promotes gastric cancer (GC) metastasis remains largely unknown."
31234902
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"Hsa_circ_0017639 expression promotes gastric cancer proliferation and metastasis by sponging miR-224-5p and upregulating USP3 ."
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"USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation."
34930901
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"USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3 / COL6A5 stabilisation ."
34930901
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"The overexpression of USP3 leads to an unfavorable prognosis in breast cancer patients and stomach cancer metastasis [34]."
38898455
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"USP3 knockdown inhibits subcutaneous tumorigenesis and distant lung metastasis in vivo."
38531846