IndraLab

Statements

Probenecid inhibits NLRP3. 10 / 10
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"Probenecid inhibited NLRP3 activation in cultured neurons and astrocytes by providing a high extracellular concentration of K + and decreased caspase-1 expression in the brains of aged rats."
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"In addition, probenecid and AZ11645373 can target the P2X7 receptor signaling pathway and inhibit the responses of the NLRP3 inflammasome during IAV infection, subsequently limiting excessive inflammation and illness during influenza (Rosli et al., 2019)."
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"In a recent study [63], our laboratory has shown, using murine macrophages, that probenecid treatment inhibits the Nod-like Receptor Protein 3 (NLRP3) inflammasome and associated MAPK signaling pathways."
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"Probenecid can inhibit the NLRP3 inflammasome response mediated through the P2X7 receptor to reduce the hyperinflammation associated with severe influenza virus infection [26]."
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"Overall, AZ11645373 and probenecid were approximately fivefold less potent than MCC950 which we have previously used (i.e., 12.5-50muM) to inhibit the effects of the NLRP3 activators and PB1-F2 (Coll et al., 2015; Pinar et al., 2017)."
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"These results show that probenecid treatment is associated with losing the catalytically active p20 subunit of cas-1, indicating that probenecid acts to abrogate cas-1 auto-proteolysis of NLRP3 inflammasomes."
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"In addition, probenecid has been shown to inhibit the NLRP3 inflammasome response, reduce hyperinflammation, and improve survival associated with severe influenza virus infection [73]."
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"Probenecid Inhibits NLRP3 Inflammasome Activity and Mitogen-Activated Protein Kinases (MAPKs)."
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"Baicalin, Probenecid, Amoxicillin, and the Combination of Probenecid and Amoxicillin Attenuated NLR Family Pyrin Domain Containing 3 (NLRP3) Inflammasome Activation in Spleen of G. parasuis-Challenged Mice."
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"Probenecid Inhibits NLRP3 Inflammasome Activity and Mitogen-Activated Protein Kinases (MAPKs)."
| PMC