IndraLab

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Probenecid inhibits NLRP3. 2 / 2
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"Probenecid inhibited NLRP3 activation in cultured neurons and astrocytes by providing a high extracellular concentration of K + and decreased caspase-1 expression in the brains of aged rats."
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"Overall, AZ11645373 and probenecid were approximately fivefold less potent than MCC950 which we have previously used (i.e., 12.5-50muM) to inhibit the effects of the NLRP3 activators and PB1-F2 (Coll et al., 2015; Pinar et al., 2017)."
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