IndraLab

Statements


UCHL5 activates Wnt. 6 / 6
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"UCHL5 knockdown enhances apoptosis and impairs Wnt/beta-catenin pathway in cervical cancer."

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"Taken together, our results clearly demonstrate that Uch37 positively regulates Wnt signalling downstream of beta-catenin stabilization."

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"UCHL5 Activated Wnt/beta-Catenin Signaling and Affected the Expression of Its Target Genes."

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"Next, either wild type Uch37 (WT) or catalytically inactive Uch37 (IN) XREF_BIBR was reintroduced to determine if Uch37 could rescue Wnt signalling."

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"Moreover, Wnt reporter activity in Xenopus embryos was completely rescued by Uch37 WT, but not by Uch37 IN mRNA (XREF_FIG)."

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"UCH37 activates Wnt signaling and affects the expression of its target genes , such as beta-catenin , cyclin D1 and c-Myc , thereby increasing the cell growth of EC ( Liu et al. 2020 ) ."