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LUF7346 activates KCNH2. 2 / 2

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"In contrast with findings described by others (Matsa etal, 2011), hERG modulation by LUF7346 completely reversed the severe effects of the potassium channel blocker AST in LQT2 N996I hiPSC-CMs, confirming the efficacy of LUF7346 compared to other molecules reported so far in the literature."

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"Collectively, these data suggested that LUF7346 activates the native hERG channels in hiPSC-CMs."

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IndraLab

Statements

LUF7346 activates KCNH2. 2 / 2

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