IndraLab

Statements

USP13 leads to the ubiquitination of MYC. 5 / 5
| 5
reach
"Further, USP13 and FBXL14 reciprocally modulate MYC polyubiquitination in GSCs ."
38503731
reach
"The phosphorylation of USP13 at Tyrosine 708 by CLK3 is required for USP13′s binding to c-Myc, which prevents its Fbxl14-mediated ubiquitination of c-Myc in glioma stem cells [10]."
36612196
reach
"Silencing FBXL14 alongside USP13 disruption attenuated the increased c-Myc ubiquitination caused by USP13 disruption (XREF_FIG)."
27923907
reach
"USP13 mediates ubiquitination of c-Myc to antagonize FBXL14 mediated ubiquitination and thus maintains the stem cell like phenotype and tumorigenic potential of GSCs."
27923907
reach
"20 In addition, USP13 is aberrantly overexpressed in ovarian cancers, and USP13 drives ovarian cancer metabolism by deubiquitinating ATP citrate lyase and oxoglutarate dehydrogenase.21 USP13 disruption inhibited the proliferation of glioma stem cells by promoting the ubiquitination and degradation of c-Myc."
31802942