IndraLab

Statements

USP6 activates Cell Survival. 7 / 7
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"The overactive USP6 protein promotes cell survival, proliferation, and resistance to apoptosis, all of which are significant features of cancer growth."
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"In contrast , absence of USP6 caused a significant decrease in cell survival versus NT control siRNA cells after high-LET alpha - particle irradiation ( Fig. 2B , 2D ) and high-LET protons ( Fig. 2F , 2H ) ."
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"Conversely, overexpression of USP6 or GOLPH3 caused a notably higher cell viability in colon cancer cells than the LV-vector group, with a significant increase in colony numbers ( Fig. 3 A, B)."
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"Jak1 is required for STAT3 activation by USP6, and both are required for USP6 mediated cell survival and tumorigenesis."
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"Using high-LET protons (Fig. 1C; Fig. E1B, available online at https://doi.org/10.1016/j.ijrobp.2019.02.053), depletion of USP6 (plus CYLD, USP7, USP31, and USP9X) also reduced cell survival by >40%."
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"Depletion of USP6 decreased cell survival specifically after high-LET alpha-particles and protons, but not low-LET protons or x-rays."
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"This approach identified ubiquitin specific protease 6 ( USP6 ) , which modulates cell survival after high-LET IR by promoting efficient repair of CDD sites ."
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