IndraLab

Statements

USP28 increases the amount of MVP. 3 / 3
| 3
reach
"Silencing of USP28 can limit the expression of MVP enzymes with a lower metabolic flux, and a dual USP28/25 inhibitor reduces viability of LSCC cells [155]."
38841622
reach
"We found that depletion of USP28 reduces the expression of multiple MVP proteins, most prominently enzymes that catalyse the sequential condensation of acetoacetyl-CoA to form isoprenoid chains that are used for protein prenylation and for the synthesis important cellular metabolites, including CoQ10, dolichol and cholesterol."
37202505
reach
"Our results show that silencing of USP28 reduces expression of MVP enzymes and lowers metabolic flux into this pathway."
37202505