IndraLab

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USP22 activates phosphatidylinositol 3-kinase/protein kinase B signal transduction. 3 / 3
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"Collectively, these results suggest that USP22 activates AKT signaling via E2F6-mediated repression of DUSP1.DUSP1 has been identified as a tumor suppressor that negatively regulates tumor proliferati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, USP22 promotes cell cycle progression by regulating BMI-mediated INK4a/ARF and Akt signaling pathways [12, 32–34]."
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"To further dissect the precise mechanism by which USP22 activates the PI3K/Akt signaling pathway, coimmunoprecipitation (Co‐IP) and mass spectrometry (MS) were utilized to identify the potential direct binding partners of USP22."
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