IndraLab

Statements

OTUB1 binds YAP1. 25 / 25
4 | 4 17
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"OTUB1 interacted with YAP1 and enhanced its protein stability."
40500704
sparser
"However, whether OTUB1-YAP1 axis affects the role of SOX18 in EMS remains to be explored."
40500704
reach
"The endogenous immuno-precipitation assay indicated that OTUB1 could associate with YAP in gastric cancer cells (Fig. 5E)."
36271031
reach
"OTUB1 associated with YAP and modulated YAP protein activity and stability, which subsequently exerted its critical decisions on Hippo on or off status (Fig. 6)."
36271031
reach
"OTUB1 could associate with YAP and deubiquitinate YAP protein at multiple lysine sites, which subsequently lead to enhanced Hippo/YAP activity."
36271031
sparser
"Targeting the OTUB1‐YAP1 axis holds promise as a potential therapeutic strategy for HNSCC treatment."
37986681
sparser
"Targeting the OTUB1‐YAP1 axis holds promise for the development of novel therapeutic strategies against HNSCC."
37986681
sparser
"Furthermore, we discovered that the OTUB1‐YAP1 (Yes‐associated protein 1) axis was implicated in the malignant behaviors of HNSCC cells."
37986681
sparser
"Indeed, YAP1 protein levels exhibit an increase in precancerous and invasive HNSCC, xref and the striking observation of endogenous YAP1 hyperactivation in tongue tissues leading to swift cancer development strongly implies the role of YAP1 in triggering the onset and progression of HNSCC. xref These findings suggest that OTUB1‐YAP1 axis may play an important role in HNSCC progression."
37986681
sparser
"OUTB1 interacted with YAP protein via its OTU domain (Ovarian tumor domain) and deubiquitinated YAP at several lysine sites (K90, K280, K343, K494 and K497), which subsequently inhibited YAP degradation."
36271031
sparser
"This provides a novel direction for the development of targeted drugs that disrupt the interaction between OTUB1 and YAP, offering potential breakthroughs in HNSCC treatment."
37986681
sparser
"The screening of DUBs in the present study is unique and this study represents the first report on the role of the OTUB1‐YAP1 axis in HNSCC progression (Figure  xref )."
37986681
sparser
"The endogenous immuno-precipitation assay indicated that OTUB1 could associate with YAP in gastric cancer cells (Fig. xref )."
36271031
sparser
"We made these deletion constructs for interaction analysis, which revealed that the WW domain was required for YAP to interact with OTUB1 while the OTU domain was necessary for OTUB1 to associate with YAP (Fig. xref )."
36271031
biogrid
No evidence text available
36271031
biogrid
No evidence text available
36271031
sparser
"Notably, hitpredict analysis revealed the binding of OTUB1 to YAP1."
40500704
sparser
"OTUB1 associated with YAP and modulated YAP protein activity and stability, which subsequently exerted its critical decisions on Hippo on or off status (Fig. xref )."
36271031
sparser
"OTUB1 could associate with YAP and deubiquitinate YAP protein at multiple lysine sites, which subsequently lead to enhanced Hippo/YAP activity."
36271031
sparser
"In addition, a study revealed that OTUB1 binds to the YAP protein via its OTU region and removes ubiquitin from YAP at various lysine locations (K90, K280, K343, K494, and K497), thereby preventing YAP degradation ( xref )."
39605891
biogrid
No evidence text available
36271031
biogrid
No evidence text available
36271031
reach
"This provides a novel direction for the development of targeted drugs that disrupt the interaction between OTUB1 and YAP, offering potential breakthroughs in HNSCC treatment."
37986681
sparser
"In addition, co-immunoprecipitation (co-IP) was used to analyze the binding of OTUB1 to YAP1 (Yes-associated protein 1)."
40500704
sparser
"OUTB1 interacts with YAP protein via its OTU domain (Ovarian tumor domain) and deubiquitinates YAP at several lysine sites (K90, K280, K343, K494 and K497), which subsequently inhibits YAP degradation [ xref ]."
37349820