IndraLab

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MEF2C increases the amount of SCN5A. 9 / 9
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"Recent studies have shown that the zinc-finger transcription factor, GATA4, and the myocyte enhancing factor-2C (MEF2C) enhances SCN5A transcription."
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"As demonstrated by both chromatin immunoprecipitation-quantitative polymerase chain reaction assay and an electrophoretic mobility shift assay, MEF2C enhanced SCN5A transcription by binding to a putative MEF2C binding site within SCN5A promoter region."
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"Our data indicated that HuR positively regulated MEF2C mRNA expression and that MEF2C enhanced cardiac sodium channel alpha subunit SCN5A mRNA expression, so it is of great interest to know whether overexpression of HuR increases the SCN5A mRNA expression."
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"As expected, knockdown of MEF2C dramatically decreased SCN5A mRNA expression by 22.3% (P < 0.05, Figure XREF_FIG A)."
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"MEF2C Enhances SCN5A Transcription."
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"Therefore, it is highly likely that MEF2C at least partially mediates the increase of SCN5A mRNA expression in the presence of HuR overexpression."
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"HuR upregulates MEF2C mRNA expression by protecting MEF2C mRNA from degradation, and consequently, the elevated MEF2C enhances SCN5A mRNA transcription."
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"MEF2C Mediated the Increase of SCN5A mRNA Expression in the Presence of HuR Expression."
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"These results suggest that MEF2C enhances the transcription of SCN5A through interacting with the MEF2C binding site within SCN5A promoter."
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