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Modified CACNA1C leads to the dephosphorylation of TSC1/2. 1 / 1
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"89 Thus, we hypothesize that loss of cacna1c resulting in deficient Ca v 1.2 signaling may inhibit Akt that subsequently (1) suppresses phosphorylation of TSC1/2 and increases its inhibitory effect on mTORC1 phosphorylation, and separately (2) activates PERK and induces eIF2alpha phosphorylation."