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USP28 activates accumulate HIF-1alpha protein cells. 1 / 1
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eidos
"Results Here , we report that USP28 is a SUMOylated protein in normoxia with moderate deubiquitinating activity towards HIF-1alpha in vitro , while hypoxia and HIF-1alpha activate USP28 through SENP1-mediated USP28 deSUMOylation to further accumulate HIF-1alpha protein in cells ."