IndraLab

Statements

Ethanol inhibits KCNH2. 6 / 6
1 | 5
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"Ethanol (12.5–50.0 mM) concentration-dependently inhibited I Kv1.5 and 50.0 mM ethanol inhibited I hERG , which probably caused the prolongation of APD."
28284858
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"methanol, ethanol, DMSO, acetonitrile, PEG400, inhibited the hERG K + current in a concentration-dependent manner including almost complete reversibility of block (exception: PEG400)."
17590357
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"Complete removal of the benzhydryl alcohol moiety as in entry 10 causes a decrease in both hERG affinity as well as H 1 affinity, although H 1 affinity seems to be effected to a greater extent."
19660947
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"From our results, 50.0 mM ethanol substantially suppressed I hERG , but 6.25–25.0 mM ethanol did not affect I hERG ."
28284858
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"Our previous experience with the sulfonamide series suggested that hERG inhibition could be decreased by the incorporation of ether or alcohol substituents into the alkyl chains."
22172695
ctd
No evidence text available
28284858