IndraLab

Statements

Ethanol inhibits KCNH2. 5 / 6
1 | 5
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"Ethanol (12.5–50.0 mM) concentration-dependently inhibited I Kv1.5 and 50.0 mM ethanol inhibited I hERG , which probably caused the prolongation of APD."
28284858
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"methanol, ethanol, DMSO, acetonitrile, PEG400, inhibited the hERG K + current in a concentration-dependent manner including almost complete reversibility of block (exception: PEG400)."
17590357
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"Complete removal of the benzhydryl alcohol moiety as in entry 10 causes a decrease in both hERG affinity as well as H 1 affinity, although H 1 affinity seems to be effected to a greater extent."
19660947
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"From our results, 50.0 mM ethanol substantially suppressed I hERG , but 6.25–25.0 mM ethanol did not affect I hERG ."
28284858
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"Our previous experience with the sulfonamide series suggested that hERG inhibition could be decreased by the incorporation of ether or alcohol substituents into the alkyl chains."
22172695