IndraLab

Statements

OTUB1 is ubiquitinated. 11 / 11
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"RNF126 promotes ubiquitination of OTUB1, leading to reduced deubiquitinating activity towards TRAF3."
34643674
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"We verified that kinase MAPK3, methyltransferase PRMT1, protein phosphatases PPP3CA and PGAM5, and deubiquitinase OTUB1 were ubiquitinated by E4B in vitro and in HEK293 cells ( xref – xref )."
29326975
sparser
"Using the same assay, we confirmed that ubiquitination of PGAM5 and OTUB1 was dependent on E4B—their ubiquitination was significantly decreased in shE4B cells, and the ubiquitination level was restored by overexpressing E4B in shE4B cells ( xref )."
29326975
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"Moreover, after treatment with MG132, HCT116 cells transfected with OTUB1 overexpression vector presented markedly increased ubiquitination of β-Catenin, leading to suppressed β-Catenin protein expression ( xref )."
35354355
reach
"Another study revealed that circIGF2BP3 functioned as the molecular sponge of miR-328-3p and miR-3173-5p to upregulate plakophilin 3 (PKP3) expression, thereby increasing ovarian tumor (OTU) family deubiquitinase ubiquitin aldehyde binding 1 (OTUB1) level and facilitating PD-L1 deubiquitination [8]."
40158127
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"Solasonine, an alkaloid constituent of Solanum nigrum L., has induced ferroptosis in PC cell lines through degradation of SLC7A11 by Otubain-1 (OTUB1)-mediated ubiquitination ( Liang et al., 2022 )."
36257540
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"Post-translational modifications including FAT10, hydroxylation, persulfidation, and ubiquitination on OTUB1 are reported to regulate its DUB activity ( xref ; xref ; xref ; xref ; xref ) ( xref )."
38264570
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"Suppression of OTUB1 with two different shRNAs resulted in increased levels of NRAS monoubiquitination (Fig  xref A), whereas overexpression of wt OTUB1 almost completely abolished ubiquitination of RAS proteins (Fig  xref B–D)."
26881969
sparser
"The levels of the lysine and serine ubiquitination of OTUB1 are further regulated by effectors that function to antagonize the activities of SidC, SdcA and SidEs, including Lem27, DupA, DupB, SidJ and SdjA."
38818749
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"In vivo, in vitro, and patient cohort analyses, demonstrated that OTUB1-TRIM28 ubiquitination plays a crucial role in modulating MYC pathway and influencing patient prognosis."
40854820
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"OTUB1 is regulated by a more stringent posttranslational network due to its core deubiquitinase function, and the ubiquitination and phosphorylation of OTUB1 were studied in this paper."
34875341