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USP22 activates ERK. 4 / 4
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"Western blot analysis showed that USP22 overexpression also induced activation of the RAS/ERK and PI3K/AKT pathways in SGC7901 cells and xenograft tumor tissues."
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"USP22 can activate extracellular signal–regulated kinase 1/2 (ERK1/2) to promote the conversion of microtubule-associated protein 1A/1B-light chain 3 (LC3) to the lipid-modified form of LC3 (LC3-II) i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Activation of ERK1/2 kinase rather than AKT1 by USP22 was found to be one of the mechanisms promoting LC3 processing."
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"USP22 overexpression in gastric cancer cells induces the upregulation of SOS1 and activation of the RAS/ERK and PI3K/AKT pathways."
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