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USP4 deubiquitinates HDAC2. 12 / 12
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"USP4 inhibits p53 and NF-kappaB through deubiquitinating and stabilizing HDAC2."
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"Taken together, our results suggested that TRPS1 stabilized HDAC2 by functioning as a scaffold protein to bring UPS4 and HDAC2 together forming the TRPS1-UPS4-HDAC2 complex to enhance USP4-directed HDAC2 de-ubiquitination."
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"Another DUB, USP4 deubiquitinates HDAC2 (Histone deacetylases 2) that was shown to interact with p53 thereby inhibiting the level of acetylated p53."
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"XREF_BIBR, XREF_BIBR Of note, our studies show that USP4 deubiquitinates and stabilizes HDAC2 and the expression of USP4 correlates with that of HDAC2 in cancer tissues (XREF_FIG)."
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"Although USP4 alone could reduce HDAC2 ubiquitination level, additional overexpression of TRPS1 significantly enhanced the reduction of HDAC2 ubiquitination (Fig. 3l)."
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"As we demonstrated that USP4 deubiquitinates HDAC2, it is possible that USP4 can stabilize HDAC2."
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"Nonetheless, USP4 might deubiquitinate and stabilize both ARF-BP1 and its substrate HDAC2."
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"However, the mechanism by which USP4 mediates HDAC2 de-ubiquitination contributing to cancer remains unclear.In this study, we show that the TRPS1-USP4-HDAC2 regulatory axis is involved in tumor cell proliferation."
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"Significantly, our results revealed the scaffolding function of TPRS1 in USP4-directed HDAC2 de-ubiquitination and provided new mechanistic insights into the crosstalk between TRPS1, ubiquitin, and histone modification systems leading to tumor growth."
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"Furthermore, our results identified the novel non-transcription factor scaffolding function of the GATA family member TRPS1 in USP4-directed HDAC2 de-ubiquitination."
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"Collectively, our data indicate that USP4 deubiquitinates and stabilizes HDAC2 protein."
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"USP4 suppresses HDAC2 ubiquitination."
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