IndraLab

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USP4 deubiquitinates HDAC2. 8 / 8
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"Nonetheless, USP4 might deubiquitinate and stabilize both ARF-BP1 and its substrate HDAC2."

"USP4 inhibits p53 and NF-kappaB through deubiquitinating and stabilizing HDAC2."

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"Collectively, our data indicate that USP4 deubiquitinates and stabilizes HDAC2 protein."

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"Another DUB, USP4 deubiquitinates HDAC2 (Histone deacetylases 2) that was shown to interact with p53 thereby inhibiting the level of acetylated p53."

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"Significantly, our results revealed the scaffolding function of TPRS1 in USP4 directed HDAC2 de-ubiquitination and provided new mechanistic insights into the crosstalk between TRPS1, ubiquitin, and histone modification systems leading to tumor growth."

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"USP4 suppresses HDAC2 ubiquitination."

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"XREF_BIBR, XREF_BIBR Of note, our studies show that USP4 deubiquitinates and stabilizes HDAC2 and the expression of USP4 correlates with that of HDAC2 in cancer tissues (XREF_FIG)."

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"As we demonstrated that USP4 deubiquitinates HDAC2, it is possible that USP4 can stabilize HDAC2."