IndraLab

Statements

Phosphorylated TP53 increases the amount of TP53. 7 / 7
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"The Chk signal transducers induce cell cycle arrest by phosphorylation of two critical effectors : inhibitory phosphorylation of the Cdc25 phosphatase results in CDK inactivation, while the activating phosphorylation of the p53 tumor suppressor stabilizes p53 and increases transcription of p53 target genes, including the cyclin dependent kinase inhibitor p21/CIP1/WAF-1."
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"In vitro studies have shown that stress-activated kinases such as ATM and CHEK2 can phosphorylate p53 thereby increasing phosphorylated-p53 levels."
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"In response to stress and DNA damage, p53 is phosphorylated on multiple serine residues, including Ser 15, resulting in inhibition of degradation and increased p53 levels."
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"This hypothesis can be supported by many studies: She et al. found that in the tumor cells treated by Res, p53 formed a complex with activated ERK and p38 kinase [17] , and such action would cause the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In response to cellular stress signaling, like oxidative signaling or DNA damage , p53 is rapidly phosphorylated which abolishes binding to MDM2 and leads to quickly elevated p53 levels due to reduced MDM2-mediated ubiquitination and degradation ."
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"1 For example, phosphorylation and acetylation of p53 have been shown to promote the expression of p53 transcriptional targets, whereas other modifications, such as ubiquitination, sumoylation, and neddylation have been associated with the suppression of p53 mediated transcription and p53 nuclear export."
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"Cellular stresses such as irradiation, lead to phosphorylation and dissociation of p53 and MDM2, which allow p53 protein levels to increase."
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