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USP8 inhibits CASP3. 2 / 2
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"In addition, the apoptosis of Cholangiocarcinoma cells was significantly increased upon USP8 knockdown by suppressing the BCL-2 (an anti-apoptotic protein) and up-regulating pro-apoptotic proteins cle[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"And Artonin F, a flavonoid isolated from Artocarpus gomezianus, can block the deubiquitination of USP8, inhibit PI3K/AKT/mTOR signaling pathway, up-regulate the expression of Bax, down-regulate the ex[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"