IndraLab

Statements

SOS1 binds DOK3 and GRB2. 5 / 5
| 1 4
sparser
"DOK3 contributes to the regulation of ERK activation downstream of LPS signaling and the formation of a Grb2-SOS1-DOK3 complex appears to limit ERK activation."
22761938
reach
"DOK3 contributes to the regulation of ERK activation downstream of LPS signaling and the formation of a Grb2, SOS1, and DOK3 complex appears to limit ERK activation."
22761938
sparser
"DOK3 was associated with Sos1 and Grb2 in unstimulated wild-type macrophages, but the extent of this association was considerably increased in response to low-dose LPS."
23962980
sparser
"Whereas our current studies showed that the association of DOK3 with Sos1 and Grb2 in response to low-dose LPS was required to inhibit ERK activation, at higher concentrations of TLR ligands, including LPS at >100 ng/ml and CpG at 0.5 µM, DOK3 becomes ubiquitinated and degraded ( xref )."
23962980
sparser
"These data suggest that the DAP12-dependent tyrosine phosphorylation of DOK3 is required for the association of DOK3 with Grb2 and Sos1."
23962980