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OTUD5 leads to the dephosphorylation of MAP3K7. 2 / 2
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"Together, OTUD5 negatively regulates TAK1-MAPK activation and inflammation in podocytes under HG/PA treatment.Then, we tried to explore how OTUD5-mediated TAK1 deubiquitination prevents TAK1 phosphorylation."

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"Western blot assay confirmed that OTUD5 overexpression significantly inhibited HG/PA-induced TAK1 phosphorylation in podocytes but did not change the total TAK1 protein level (Fig. 5a, Supplementary Fig. 5a)."