IndraLab

Statements

USP1 inhibits cell cycle. 4 / 4
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"Downregulation of USP1 blocked OV cell cycle in vitro ."
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"Further, ML323 targets USP1, thereby inhibiting the proliferation of OV cells by blocking the progression of the OV cell cycle, thus achieving inhibition of tumor proliferation."
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"The results showed that knockdown of USP1 induced the upregulation of cell cycle-arresting protein such as P27 and downregulation of proteins promoting cell cycle progression such as CyclinB1, CyclinA2, CyclinD3 and CDK4 (Fig. 2i)."
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"As reported in Figure XREF_FIG A, USP1 depleted U2OS cells re-enter the cell cycle more rapidly than USP1-proficient cells, suggesting that USP1 depletion could accelerate recovery from the G2 checkpoint."
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