IndraLab

Statements

OTUD6A activates cell population proliferation. 5 / 8
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"Knockdown of OTUD6A inhibited the cell proliferation (Fig. 4d, e)."
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"Moreover, OTUD6A is expressed at high levels in breast cancer, and OTUD6A overexpression promotes cell proliferation, migration and invasion, indicating that dysregulation of OTUD6A expression contributes to genomic instability and is associated with tumor development."
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"Moreover, OTUD6A promotes cell proliferation and decreases sensitivity to chemotherapy by upregulating CDC6."
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"Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission."
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"We further showed that OTUD6A, through upregulation of CDC6, promotes the proliferation of multiple types of human tumour cells in vitro and tumour growth in vivo, suggesting the importance of OTUD6A-CDC6 axis in these cancer cells."
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