IndraLab

Statements

TNF increases the amount of COPS5. 10 / 10
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"TNF-alpha Upregulates CSN5 Expression to Stabilize PD-L1."
27866850
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"Among the 52 deubiquitinating enzymes identified, CSN5, which possesses enzyme activity in the COP9 signalosome, was robustly expressed in response to TNF-alpha treatment in three cell lines examined (XREF_FIG)."
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"TNFalpha upregulates CSN5 expression through activation of the transcription factor NF-kappaB p65, which directly transactivates the promoter of the CSN5 encoding gene."
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"In addition, Lim et al. found that TNF-α upregulates the expression of ubiquitin enzyme CSN5, which reduces the ubiquitination of PD-L1 and stabilizes its expression (41)."
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"It was reported that TNF-α can promote the transcription of CSN5 through activation of the NF-κB signaling pathway."
| PMC
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"Proinflammatory cytokine TNFalpha, secreted by M2 macrophages, induces CSN5 expression through IKKbeta and NF-kappaB activation."
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"The results suggested that TNF-alpha upregulates expression of CSN5, which interacts and deubiquitinates PD-L1 for protein stabilization."
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"Mechanistically, TNF-alpha may activate NF-kappaB and induce CSN5 expression, leading to PD-L1 stabilization."
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"NF-κB pathway activated by TNF-α induced CSN5 expression to stabilize PD-L1 expression in cancer cells. xref Palmitoylation of PD-L1 at C272 by DHHC3 blocked mono-ubiquitination of PD-L1 and the subsequent ESCRT-mediated trafficking to multivesicular bodies (MVB), resulting in suppression of PD-L1 lysosomal degradation. xref "
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"The pro-inflammatory cytokine TNF-α induces the expression of the deubiquitinase CSN5 which deubiquitinates PD-L1 for stabilization (Figure 3), revealing a novel mechanism of immune escape under chronic inflammatory microenvironment [231]."
| PMC