IndraLab

Statements

Vandetanib inhibits KCNH2. 16 / 16
| 3 13
reach
"Vandetanib inhibited WT-hERG current by approximately 86.4 +/- 7.3% (XREF_FIG)."
29630634
reach
"Vandetanib at concentrations of 0.3, 1, and 3 muM reduced I hERG current amplitude by 17.04, 45.32, and 76.05%, respectively (n = 4; XREF_FIG)."
29630634
reach
"Therefore, we speculated that the combination of Gin Rg3 and vandetanib could reverse vandetanib-induced hERG current inhibition and then alleviated the prolongation of QT interval induced by vandetanib."
34659631
reach
"Studies have reported that vandetanib can prolong hiPSC-CM action potential and inhibit hERG current, as well as inhibit both sodium current and calcium current [22]."
34659631
reach
"84 Vandetanib inhibits hERG/KCNH2 channels decreasing IKr current amplitude, leading to a long QT."
35087712
reach
"Furthermore, ginsenoside Rg3 alleviated vandetanib-induced hERG current inhibition and accelerated the process of the channel activation."
34659631
reach
"The results showed that vandetanib exerts blocking effects on both the opening and closing states of hERG channels.The time-dependent effect of vandetanib on hERG channel blocking was produced by the whole-cell patch-clamp technique."
34659631
eidos
"Patch-clamp recordings revealed significant reductions of hERG current densities by nilotinib or vandetanib after chronic incubation with hERG-HEK293 cells in addition to the acute inhibition ."
35680041
eidos
"Downregulation of hERG Channel Expression By Tyrosine Kinase Inhibitors Nilotinib And Vandetanib Predominantly Contributes To Arrhythmogenesis ."
35680041
reach
"Western blot analysis showed that nilotinib and vandetanib decreased mature hERG protein (155-kDa) expression, in a greater extent than that of the immature form (135-kDa)."
35680041
reach
"In stable transfected human hERG gene HEK293 cells, vandetanib caused concentrate-dependent inhibition in the step and tail currents of hERG."
34659631
reach
"However, the dynamic characteristics of hERG channel current were not studied, and the specific mechanism of prolongation of action potential was not clear.In this study, we analyzed the hERG current dynamic characteristics of vandetanib and found that vandetanib concentration-dependent inhibited the activation of hERG current and the end current of depolarization."
34659631
reach
"Lee et al. [22] found that vandetanib inhibited hERG current, I and I ."
34659631
reach
"Purkinje fiber assays and ion channel studies showed that vandetanib at concentrations of 1 and 3 muM inhibited the hERG currents and prolonged the action potential duration."
29630634
eidos
"For example , pre-clinical studies reveal that vandetanib causes hERG block at low concentrations and is associated with both AP prolongation in cardiac tissue preparation and QTc prolongation in vivo suggesting a classical drug-channel interaction [ 226 ] ."
33404052
reach
"The Time Dependence of Gin Rg3 on Vandetanib-Induced hERG Channel Blocking."
34659631