IndraLab

Statements

NCOR2 decreases the amount of USP17L2. 5 / 5
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"These data suggest that NCOR2 and HDAC10 work in concert in the same complex to repress expression of DUB3 in prostate cancer cells."
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"Our current findings show that NCOR2, functioning as a transcriptional repressor, represses DUB3 expression."
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"Based on these genomic data and our finding that NCOR2 represses DUB3 expression in cultured cells, we hypothesized that loss of NCOR due to deletions or mutations results in DUB3 upregulation, which [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We found that knockdown of NCOR2 by two independent shRNAs increased expression of DUB3 and BRD4 proteins, but not BRD2 and BRD3 proteins, while NCOR2 knockdown increased mRNA expression of DUB3, but [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We demonstrated that NCOR2 represses DUB3 expression by specifically interacting with HDAC10."
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