IndraLab

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STAT3 decreases the amount of USP7. 5 / 6
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"USP7 mRNA and protein levels are decreased in colon cancer cells and IL-6 stimulates STAT3 activation suppressing USP7 expression, resulting in the degradation of p53.44 45Recent studies have shown new interacting proteins for USP7."
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"We also suggest that IL-6 induced STAT3 activation represses USP7 expression, leading to the degradation of P53."
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"Consistent with this, HDAC class I and class II inhibitor trichostatin A (TSA) abolished STAT3-mediated repression of USP7 transcription ( Fig. 3 C) [9] , suggesting that STAT3 recruits nuclear HDAC t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We also suggest that STAT3 activation down-regulates USP7 expression, leading to the degradation of p53."
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"Besides, overexpression of a constitutively activated STAT3 (STAT3C) also repressed the expression levels of USP7 ( Fig. 2 C and D)."
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