IndraLab

Statements

AMFR activates ATXN3. 2 / 3
| 2
reach
"ER associated E3 ubiquitin ligase Autocrine Motility Factor Receptor (AMFR) or Gp78 induces the degradation of Superoxide Dismutase 1 (SOD1) and ataxin-3 and provides cytoprotection against mutant SOD1 induced toxicity XREF_BIBR."
24865853
reach
"The involvement of Gp78 in neuroprotection came into existence with studies based on disease associated aggregatory proteins superoxide dismutase-1 (SOD1) and ataxin-3, which are targeted by Gp78 for ubiquitination and proteasomal degradation."
28890687