Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

AMFR activates ATXN3. 2 / 3

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"ER associated E3 ubiquitin ligase Autocrine Motility Factor Receptor (AMFR) or Gp78 induces the degradation of Superoxide Dismutase 1 (SOD1) and ataxin-3 and provides cytoprotection against mutant SOD1 induced toxicity XREF_BIBR."

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"The involvement of Gp78 in neuroprotection came into existence with studies based on disease associated aggregatory proteins superoxide dismutase-1 (SOD1) and ataxin-3, which are targeted by Gp78 for ubiquitination and proteasomal degradation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...