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"Therefore, UCHL3 might suppress the ubiquitin-driven degradation of CTNNB1 and thereby trigger the Wnt signaling pathway, resulting in tumorigenic promotion.Although the stabilization of UCHL3 depends on its deubiquitinating activity, UCHL3 directly deubiquitinates CTNNB1, and the sites of CTNNB1 that are deubiquitinated by UCHL3 need to be identified.In summary, we showed that UCHL3 expression is amplified in bladder cancer and functions as a tumor promoter that enhances the proliferation and migration of bladder cancer cells in vitro and to bladder tumorigenesis and tumor progression in vivo."