IndraLab

Statements

USP15 activates X. 6 / 6
| 6
reach
"This implied that the association of USP15 with HBx not only increases the stability of HBx but also augments HBx mediated oncogenic signals."
28074857
reach
"USP15 enhances the transactivation activity of HBx."
28074857
reach
"USP15 attenuates HBx degradation through deubiquitination of HBx."
28074857
reach
"There results clearly indicate that USP15 attenuates the degradation of HBx."
28074857
reach
"We found that USP15 mediated deubiquitylation protects HBx from proteasomal degradation thus increasing the stability and level of HBx protein as well as its transactivation activity."
28074857
reach
"Since we have shown that USP15 is essential for maintaining HBx stability and that USP15 augments HBx mediated oncogenic signals, one inference from our work is that compromising USP15 might be a novel approach to abrogate cellular transformation and serve as a target for anti-cancer therapy."
28074857