IndraLab

Statements

Parthenolide inhibits IKBKB. 8 / 8
| 5 3
reach
"A well-studied constituent, parthenolide, specifically binds to and inhibits IKK-beta, which is involved in cytokine-mediated signaling."
| PMC
reach
"The IKK inhibitors parthenolide and aspirin blocked the activities of infection induced IKKalpha and IKKbeta, leading to attenuation of nuclear translocation of NF-kappaB."
15618150
sparser
"However, the fact that parthenolide can inhibit a constitutively active IKKβ (SS/EE) mutant does not support this hypothesis as the sole mechanism."
11514225
sparser
"Since IKKβ, IKKα, and the upstream kinase MEKK1 have been previously reported not to be the target of parthenolide [19] , and we show here that parthenolide inhibits IκB phosphorylation in response t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11514225
reach
"We show that parthenolide effectively inhibits the IKK activity of a constitutively active IKKbeta (SS/EE mutant), thus demonstrating that parthenolide acts at the level of IKKbeta."
11514225
reach
"The molecular mechanism of IKKbeta inhibition by parthenolide remains unknown."
11514225
sparser
"The molecular mechanism of IKKβ inhibition by parthenolide remains unknown."
11514225
reach
"To exclude the possibility that parthenolide prevents IKKbeta activation via inhibition of an upstream kinase, constitutively active IKKbeta was tested for sensitivity to parthenolide."
11514225