IndraLab

Statements

Parthenolide inhibits IKBKB. 9 / 9
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"The IKK inhibitors parthenolide and aspirin blocked the activities of infection induced IKKalpha and IKKbeta, leading to attenuation of nuclear translocation of NF-kappaB."
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"To exclude the possibility that parthenolide prevents IKKbeta activation via inhibition of an upstream kinase, constitutively active IKKbeta was tested for sensitivity to parthenolide."
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"Since IKKβ, IKKα, and the upstream kinase MEKK1 have been previously reported not to be the target of parthenolide [19] , and we show here that parthenolide inhibits IκB phosphorylation in response t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the other hand, a number of studies have now shown that the SL parthenolide also inhibits the IKKβ by alkylating a cysteine residue in its activation loop (Hehner et al., 1999; Kwok et al., 2001) ."
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"We show that parthenolide effectively inhibits the IKK activity of a constitutively active IKKbeta (SS/EE mutant), thus demonstrating that parthenolide acts at the level of IKKbeta."
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"The molecular mechanism of IKKbeta inhibition by parthenolide remains unknown."
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"17,18,20,21 Similar to these compounds, the sesquiterpene lactone parthenolide contains an α-methylene γ-lactone group and inhibits IKKβ by covalently binding to Cys-179."
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"The molecular mechanism of IKKβ inhibition by parthenolide remains unknown."
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"However, the fact that parthenolide can inhibit a constitutively active IKKβ (SS/EE) mutant does not support this hypothesis as the sole mechanism."
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