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Tat decreases the amount of KCNH2. 6 / 6
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"The MTT assay showed that HIV Tat protein at 50 and 200 ng/ml had no effect on the cell viability, indicating that inhibition of hERG channel expression by HIV Tat protein is not related to the cytoto[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We further performed the immunocytochemistry analysis and the results confirmed that HIV Tat protein inhibited hERG protein expression."
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"HIV Tat protein incubation (200 ng/ml) for 24h had no effect on the hERG mRNA expression, but dose-dependently inhibited hERG protein expression."
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"HIV Tat protein increased reactive oxygen species (ROS) generation and the inhibition of hERG channel protein expression by HIV Tat protein was prevented by antioxidant tempol."
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"We found that HIV Tat protein, the product of regulatory HIV genes, inhibited hERG K + currents and hERG channel protein expression."
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"The present data showed that HIV Tat protein inhibited hERG channel protein expression but had no effect on hERG channel mRNA expression, indicating that HIV Tat protein inhibits the translation step [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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