IndraLab

Statements

1 binds CALM1. 8 / 8
| 8
sparser
"Inhibitory Killer Cell Immunoglobulin-Like Receptors KIR2DL1 and KIR2DL2/3 are reduced in both BP- and CAM-dNK cells at term compared to first trimester dNK. xref , xref At baseline, dNK and PB-NK express cytolytic molecules (PFN, GZMB, GNLY); however, PB-NK have higher PFN and GZMB and first trimester dNK (but not term dNK) have higher GNLY and 9kD GNLY. xref Unstimulated, first trimester dNK, but not PB-NK, secrete proangiogenic cytokines and growth factors (IL-6, VEGF, PLGF). xref , xref These data are supportive of a role for dNK in vascular remodeling in early gestation."
41279445
sparser
"Although certain activation receptors ( CD69 , NKp80 , NKp44 ) are expressed at the RNA level in CAM-dNK, but not in BP-dNK, functional and protein expression differences have not yet been identified. xref , xref - xref dNK function and functional receptor expression are distinct between first trimester and term (including between BP and CAM)- however, the basis for this functional change remains unclear."
41279445
sparser
"However, term dNK from the two compartments do show gene expression differences. xref scRNA-seq analyses have pointed to a relative increase in dNK in CAM, but not BP, in placentas of patients with preterm labor. xref Further, labor-associated differential interactions were identified for BP-dNK and CAM-dNK. xref We reanalyzed the Pique-Regi, 2019 scRNA-seq dataset and identified similar differences between BP- and CAM-dNK. xref Notably, we found that ~50% of the dNK in CAM are dNK2, similar to first trimester, while the dNK2 population is reduced (to 23%) in BP."
41279445
sparser
"Term BP- and CAM-dNK have higher activation responses than first trimester dNK. xref When first trimester dNK is sub-stratified by subtype, dNK3 has the highest effector response, followed by dNK2, and then dNK1. xref In agreement with the literature, we found markers associated with decreased effector function (CD9, KIR2DL1 and CD39) to be higher in first trimester dNK, while activating receptors (CD18, CD103, and CD69) was increased at term, in both BP and CAM ( xref - xref )."
41279445
sparser
"We analyzed the secretomes of first trimester dNK, term BP-dNK and CAM-dNK, and peripheral blood NK cells to identify proteomic profiles for each."
41279445
sparser
"We also report, for the first time, that the high IL-6 and PLGF are in fact specific to first trimester dNK, as their levels are lower in BP-dNK and CAM-dNK, similar to PB-NK, secretomes."
41279445
sparser
"In comparison to BP-dNK, CAM-dNK had greater abundance of moderate-effector-function dNK2 and lower expression of inhibitory CD9."
41279445
sparser
"Meanwhile, dNK1 made up only 6% of BP-dNK and 5% of CAM-dNK, while ≥0.1% of all term dNK mapped to dNKp ( xref )."
41279445