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LEP inhibits USP28. 2 / 2
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"Here, we applied a recently reported USP28-specific inhibitor OB and showed that selective inhibition of USP28 by OB abrogates TAC-induced established hypertrophic heart failure and oxidative stress, indicating OB as a potential candidate for the treatment of heart failure."
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"Otilonium Bromide (OB), which is known as an antimuscarinic and calcium channel blocker and used for the treatment of uncontrollable abdominal pain, was identified to inhibit USP28′s enzymatic activit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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