IndraLab

Statements

FlaG binds KCNH2. 6 / 6
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"As shown in Fig. 1 B, transient expression of Hsp90 increased the mature form of HERG-FLAG (depicted by ∗∗)."
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"Overexpressed Hsp90 also inhibited the binding of endogenous C-terminus of Hsp70-interacting protein (CHIP) to HERG-FLAG proteins."
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"CHIP overexpression decreased both mature and immature forms of HERG-FLAG proteins in cells treated with GA."
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"To study the effects of Hsps on Kv1.5-FLAG or HERG-FLAG protein stability, we used COS7 cells or HEK293 cells for transient expression and HeLa cells stably expressing heat shock factor 1 (HeLa/HSF-1)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"COS7 cells or HEK293 cells were co-transfected with Kv1.5-FLAG cDNA (2 μg) or HERG-FLAG cDNA (2 μg) and either pcDNA3/Hsp70 (2 μg) or pcDNA3/Hsp90 (2 μg) together with pEGFP (0.5 μg), keeping the tota[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It recognizes N-terminally tagged exogenous rabbit MYC-K v 11.1 WT at ~ 145 kDa, but not FLAG-Kv11.1 7bp−del in HEK cells (Supplementary Fig.  xref A)."
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