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HCN4 activates cardiac I(f) channels. 1 / 1
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"In heterologous cells, the C-terminal-truncated HCN2 protein co-assembles with HCN4 to form functional heteromeric HCN channels, which activate faster than homomeric HCN2 or homomeric HCN4 channels, and display properties similar to endogenous myocardial I (f) channels Taken together, these results suggest that functional myocardial I (f) channels reflect the heteromeric assembly of HCN2 and HCN4 subunits and further that the HCN4 subunit underlies the cAMP mediated regulation of cardiac I (f) channels."
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