IndraLab

Statements

Vismodegib inhibits USP28. 3 / 3
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"USP28 and USP25 are down-regulated by Vismodegib in vitro and in colorectal cancer cell lines."
32578360
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"Indeed, vismodegib decreases the activity of USP25 and USP28 as well as their substrates, such as c-MYC, in CRC cells[30,89]."
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"Compared to Vismodegib, which is a moderate inhibitor of USP28 (IC 50 = 4.81 ± 1.65 μM), the inhibition activities of 9l , 9o and 9p against the enzyme are much stronger."
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