IndraLab

Statements

PKA binds AKAP9 and KCNQ1. 3 / 3
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"We have previously shown that adenylyl cyclase Type 9 (AC9) is associated with a KCNQ1-Yotiao-PKA complex and facilitates isoproterenol-stimulated phosphorylation of KCNQ1 in an immortalized cell line."
31461851
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"Molecular mechanistic studies showed that this mutation partially inhibits protein-protein interactions of KCNQ1-AKAP9, leading to decreased PKA-mediated phosphorylation of KCNQ1."
29370121
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"As mentioned above, β ‐adrenergic receptor activation of SNS mediates an increase in cAMP leading PKA stimulation and thereby PKA interacts with KCNQ1 through Yotiao causing the phosphorylation of residue S27."
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