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Statements

CM binds CALM1. 14 / 14
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"Furthermore, A2780 invasion rates showed no differences after culture with Mϕ-CM, Cis-Mϕ-CM, CAM-CM, and Cis-CAM-CM ( Fig. S1A )."
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"This revealed that Cis-CAM-CM led to up-regulation of the mesenchymal markers N-cadherin and Snail, and down-regulation of the epithelial marker E-cadherin in A2780 cells, compared to CAM-CM ( Fig. 1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, CCK-8 experiments revealed that CAM-CM significantly decreased the survival rates of ovarian cancer cells compared to fresh DMEM and Mϕ-CM, comfirming the anti-tumor effect of CAMs, where[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, CAM-CM caused significantly more apoptosis in ovarian cancer cells than in fresh DMEM and Mϕ-CM, as demonstrated by flow cytometry-detected increase of annexin V-positive cells."
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"One possible problematic outcome of such dismissal is that patients, who already anticipate this negative response, may choose not to discuss their concurrent use of treatments with their HCP, and as such may assume the entire burden of managing the interactions of CM and CAM without any medical guidance, which puts them at a great health risk [ xref , xref ]."
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"However, there were no significant differences in apoptosis rates between the ovarian cancer cells treated with CAM-CM and Cis-CAM-CM ( Fig. 2 D and E)."
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"After culture of A2780 in DMEM, CAM-CM, and Cis-CAM-CM, there were no significant differences in the 50% inhibitory concentration (IC50) of cisplatin ( Fig. 2 F), similar to the result in SKOV3 cells [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To explore the potential mechanism by which cisplatin-stimulated CAMs promote ovarian cancer cell migration, luminex liquid suspension chip detection was adopted to compare the differential expression[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Next, we used anti-CCL20 neutralizing antibody to block the effect of CCL20 in CAM-CM and Cis-CAM-CM, and found that the migration rate of cancer cells remained unchanged after neutralizing CCL20 in C[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This revealed IL-1β, CCL20, CX3CL1, CXCL2, CXCL1, and MIF as the six most highly upregulated proteins in Cis-CAM-CM compared to levels in CAM-CM ( Fig. 3 A)."
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"In addition, the survival of CCR6-knockdown ovarian cancer cells remained unchanged upon exposure to CAM-CM and Cis-CAM-CM ( Fig. S2A–D )."
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"In transwell assays, A2780 migration was higher with CM from CAMs treated with cisplatin (Cis-CAM-CM) than with CM from untreated CAMs (CAM-CM)."
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"This knowledge could prevent potentially dangerous drug-herb or drug-drug interactions caused by the concomitant use of CAM and CM."
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"However, A2780 migration rates with CM of Mϕ (Mϕ-CM), Mϕ treated with cisplatin (Cis-Mϕ-CM), and CAM-CM showed no significant differences ( Fig. 1 D)."
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