IndraLab

Statements

BAP1 activates ITPR3. 3 / 3
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"In the cytoplasm, BAP1 modulates the stability of the IP3R3 channel, which allows the flux of Ca + from the endoplasmic reticulum into the mitochondria, where Ca + is required for the Krebs cycle and, at higher doses, to execute apoptosis."
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"Thus , loss of BAP1 leads to decreased ITPR3 expression , decreased mitochondrial Ca2 + and reduced sensitivity of cancer cells to apoptosis ."
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"Loss of BAP1 therefore leads to loss of ITPR3 , which in turn reduces apoptotic mitochondrial calcium signals [ 6 ] ."
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