IndraLab

Statements

USP17L2 activates NFE2L2. 4 / 4
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"Importantly, ectopic expression of DUB3 caused NRF2 dependent chemotherapy resistance in colon cancer cell lines."
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"Further experiments demonstrated that DUB3 promoted NRF2 stability and transcriptional activity by decreasing the K48 linked ubiquitination of NRF2."
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"DUB3 promotes Nrf2 stability and transcriptional activity by decreasing the K48 linked ubiquitination of Nrf2."
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"Moreover, these authors demonstrated that ectopic expression of DUB3 caused Nrf2 dependent chemotherapy resistance in colon cancer cell lines [XREF_BIBR]."
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