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LN5P45 inhibits OTUB2. 2 / 2

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"LN5P45 is a small-molecule inhibitor of OTUB2 with high specificity, and it inhibits the DUB activity of OTUB2 by engaging the C51 active site (Appendix Fig. S13B) (Gan et al, 2023)."

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"Since none of the other Rho-Ub-PA-labeled bands were affected by the OTUB2 inhibitor, this result indicates that LN5P45 can specifically inhibit endogenous OTUB2."

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LN5P45 inhibits OTUB2. 2 / 2

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