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Mutated SCN1A inhibits sodium atom. 2 / 2
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"SCN1A provide instructions for making alpha subunit of a sodium channel called Nav1.1, and a recent study suggested that milder phenotypes of SCN1A mutation can cause lesser impairment of Na + channel function leading to reduced Na + currents in GABAergic inhibitory interneuron or electrical network hyperexcitability in patients with these mutations."
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"Animal studies have revealed that SCN1A mutations causing loss of function of Na v 1.1 impair the firing of GABAergic neurons compared to pyramidal cells."
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