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KCNH2 inhibits calcium(2+). 8 / 8
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"Indeed, the pure hERG channel blocker, dofetilide, was shown to increase both QTc (heart rate-corrected QT) and J-T peak c (heart rate-corrected J-T peak ) intervals, while the strong L-type Ca 2+ and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Altogether, our findings strongly suggest that stimulation of the hERG1 potassium channels in breast cancer cells induces a calcium dependent degradation of cyclin E2 via activation of an ubiquitin dependent proteasome pathway."
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"Furthermore, the specific blockage of scorpion toxin BmKKx2 could suppress the expression of hERG potassium channel and decrease the Ca 2+ concentration during the erythroid differentiation of K562 cells."
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"Reduction of IKr caused by hERG block delays repolarization, increasing the probability of L-type calcium current triggering extra beats called early afterdepolarizations (EADs; Figure XREF_FIG b), which can initiate TdP."
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"Quinidine is a Class IA antiarrhythmic agent and a hERG potassium channel blocker which also blocks calcium and sodium channels at high concentration ( Kramer et al., 2013 )."
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"GIRK current recordings indicate that MPBS functions as a GPCR-dependent regulator that produces a leftward shift in the somatostatin concentration-response curve for channel activation.Arylsulfonamid[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, various studies have revealed that ATO can inhibit the expression of hERG in the endoplasmic reticulum [ 5 ], and increase the cardiac calcium current through the oxidative inactivation of PT[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Stimulation of hERG1 channel activity promotes a calcium dependent degradation of cyclin E2, but not cyclin E1, in breast cancer cells."
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