IndraLab

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KCNH2 inhibits calcium(2+). 4 / 4
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"Altogether, our findings strongly suggest that stimulation of the hERG1 potassium channels in breast cancer cells induces a calcium dependent degradation of cyclin E2 via activation of an ubiquitin dependent proteasome pathway."
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"Furthermore, the specific blockage of scorpion toxin BmKKx2 could suppress the expression of hERG potassium channel and decrease the Ca 2+ concentration during the erythroid differentiation of K562 cells."
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"Stimulation of hERG1 channel activity promotes a calcium dependent degradation of cyclin E2, but not cyclin E1, in breast cancer cells."
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"Reduction of IKr caused by hERG block delays repolarization, increasing the probability of L-type calcium current triggering extra beats called early afterdepolarizations (EADs; Figure XREF_FIG b), which can initiate TdP."
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