IndraLab

Statements

USP12 activates Prostatic Neoplasms. 5 / 5
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"It has been mentioned previously that USP12 silencing inhibits PC cell proliferation, induces cell cycle arrest, and promotes apoptosis [42]."
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"Furthermore, Usp12 silencing was shown to reduce proliferation of PC cells."
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"Depletion of USP12 decreased PC cell proliferation, increased apoptosis and caused G 1 arrest ( Burska et al., 2013 and McClurg et al., 2014 )."
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"As a result Usp12 promotes PC development with protein levels increased in PC patients compared to benign controls."
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"On the other hand, USP12 promoted prostate cancer (PC) cells proliferation by forming a complex with Uaf-1 and WDR20 and deubiquitinating AR, thereby increasing AR stability and transcriptional activity, whereas USP12 silencing led to a significant decrease in PC cell proliferation [42, 64]."
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