IndraLab

Statements

COPS5 decreases the amount of CD274. 7 / 7
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"As presented in Fig. 9A, CSN5 overexpression decreased the phosphorylation of β-catenin but increased β-catenin and PD-L1 levels."
34325342
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"The current study provided evidence suggesting that activation of CSN5 could inhibit NK cell function in GC by stabilizing PD-L1 protein level through deubiquitination."
35114597
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"Additionally, the increased β-catenin and PD-L1 protein levels and the decreased p-β-catenin level induced by PDIA6 overexpression were also reversed by CSN5 silencing (Fig. 9E)."
34325342
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"Downregulation of Jab1 decreases PD-L1 expression in cancer cells."
35971127
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"Downregulation of CSN5 reduced TNF-alpha-induced PD-L1 expression (XREF_FIG), indicating that CSN5 is required for PD-L1 stabilization."
27866850
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"Half-life analysis using cycloheximide pulse-chase analysis indicated that downregulation of CSN5, but not CSN2, which has been shown to destabilize Snail, reduced PD-L1 expression as well as its protein half-life (XREF_FIG)."
27866850
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"Silencing CSN5 in HMVEC-L led to a reduction in NF-kappaB protein levels at 4 hours and PD-L1 levels at 4, 8, and 24 hours after Der p 1 treatment."
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