IndraLab

Statements


MTOR inhibits TNFAIP3. 5 / 5
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"Moreover, inhibition of mTOR signaling reversed TNFAIP3 inhibition on both IL-1beta and TNF-alpha production (XREF_FIG, XREF_FIG)."

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"The induction of autophagy in naive CD4 T cells following TCR stimulation is dependent on mTOR inhibition downstream of the ubiquitin editing enzyme TNFAIP3 (A20) 114."

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"NFκB activator LPS and mTOR activator MHY1485 reversed the effects of TNFAIP3 on mitigation of injury in PD mice and in SK-N-SH cells induced with MPP + ."

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"Further, pharmacological inhibition of mTOR signaling can significantly reverse the effects of TNFAIP3 knockdown, including inhibition of autophagy and extracellular matrix production, as well as the promotion of inflammatory response."

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"The induction of autophagy in naïve CD4 T cells following TCR stimulation is dependent on mTOR inhibition downstream of the ubiquitin editing enzyme TNFAIP3 (A20) 114 ."