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OTULIN-C129A inhibits NFkappaB. 1 / 1

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"Interestingly, overexpression of catalytically inactive OTULIN C129A also suppressed NF-kappaB signaling, in contrast to the Ub binding mutant OTULIN W96A, likely due to the ability of OTULIN C129A to compete with endogenous UBDs involved in NF-kappaB signaling, as it is the case for Ub binding domain in ABIN proteins and NEMO (UBAN)-based Met1 Ub sensors as well [XREF_BIBR, XREF_BIBR]."

33288901

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OTULIN-C129A inhibits NFkappaB. 1 / 1

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