IndraLab

Statements

TP53 acetylated on K382 decreases the amount of TP53. 3 / 3
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"NAMPT overexpression also reduced the fraction of p53 that was acetylated on lysine 382, a target of SIRT1, suppressed an age related increase in p53 expression, and increased the rate of p53 degradation."
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"Mechanistically, irisin treatment increased Sirtuin 1 (SIRT1) and decreased p53 K382 acetylation, which decreased p53 protein expression by increasing its degradation, consequently upregulated SLC7A11 and GPX4 expressions."
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"Nampt overexpression also reduced the fraction of p53 that was acetylated on lysine 382, a target of SIRT1, suppressed an age related increase in p53 expression, and increased the rate of p53 degradation."
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